RB Leipzig and Manchester City have faced each other only three times in their history. All three matches were played in the UEFA Champions League, with Manchester City winning two matches and RB Leipzig winning one.
Their first encounter was in the group stage of the 2021-2022 Champions League, with Manchester City winning 6-3 at home on September 15, 2021. In the reverse fixture on November 24, 2021, RB Leipzig won 2-1 at home.
The two teams also met in the quarter-finals of the 2020-2021 Champions League, with Manchester City winning both matches. They won 2-1 in the first leg in Manchester on April 6, 2021, and 2-0 in the second leg in Leipzig on April 14, 2021.